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    Bioprocess Technology FHNW

    Production of recombinant proteins and viral vectors

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    • Produce recombinant proteins, viral vectors, plasmid DNA and other complex molecules for research and industrial projects
    • Develop production and purification processes
    • Model and analyze data for biotech processes
    • Implement process analytical technologies
    • Train staff to work in biomanufacturing facilities
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    Virtual Tour
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    Competencies
    • Bioprocessing
    Competencies (detailed)
    • Microbial cell culture (E. coli, P. pastoris, etc)
    • Mammalian cell culture (CHO-S, CHO-K1, HEK293F, HEK293T, etc)
    • Development and optimization of media and production processes
    • Design and simulation of upstream and downstream processes
    • Execution of batch, fed-batch and continuous processes including alternating tangential flow (ATF) and tangential flow filtration (TFF)
    • Preparative protein chromatography
    • Process analytical technologies (PAT) for process monitoring
    • Digital technologies for process improvement: data visualization and advanced modeling
    • Scale-up of processes and production of product samples at the FHNW Process Technology Center (PTC)
    • Development of formulation in collaboration with Prof. Dr. Oliver Germershaus (FHNW)
    Infrastructure
    • Bioreactors
    • Purification
    • Chromatography
    Infrastructure (detailed)
    • Bioreactors for bacterial cultures: from 1 mL to 100 L
    • Bioreactors for mammalian cell cultures: from 1 mL to 10 L
    • High-throughput shaken cultivation systems (bacterial and mammalian)
    • Membranes and hollow fibers for cell and protein separation
    • Ultracentrifuge and pilot scale centrifugation
    • Clarification from small scale to pilot scale
    • Purification equipment: chromatography columns from 1 mL to 1000 mL (Äkta Avant, Äkta Pilot, ChromaCon Cube, Biorad)
    • Tangential flow filtration (TFF) units, ultrafiltration and diafiltration (UF/DF) (Pall Centramate, Äkta Flux)
    • Inline/online sensors (Raman, IR, capacitive sensors)
    Biotechnet platforms
    Biomanufacturing
    Training for Pharma / Biotech
    Successful projects
    Intelligent textiles for masks
    Group leader
    Thomas Villiger
    Academic institution
    FHNW - University of Applied Sciences and Arts Northwestern Switzerland
    Location

    Hofackerstrasse 30, 4132 Muttenz, Switzerland

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    Events
    Continuous Chromatography for Biotherapeutics
    10th Advanced Process Data Analytics
    Symposium: Digital Innovation in BioPharma
    11th Advanced Process Data Analytics
    Continuous Chromatography for mAbs/Oligonucleotides and Peptides
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