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Bioprocess Technology FHNW
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Production of recombinant proteins and viral vectors
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Produce recombinant proteins, viral vectors, plasmid DNA and other complex molecules for research and industrial projects
Develop production and purification processes
Model and analyze data for biotech processes
Implement process analytical technologies
Train staff to work in biomanufacturing facilities
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Competencies
Bioprocessing
Competencies (detailed)
Microbial cell culture (E. coli, P. pastoris, etc)
Mammalian cell culture (CHO-S, CHO-K1, HEK293F, HEK293T, etc)
Development and optimization of media and production processes
Design and simulation of upstream and downstream processes
Execution of batch, fed-batch and continuous processes including alternating tangential flow (ATF) and tangential flow filtration (TFF)
Preparative protein chromatography
Process analytical technologies (PAT) for process monitoring
Digital technologies for process improvement: data visualization and advanced modeling
Scale-up of processes and production of product samples at the FHNW Process Technology Center (PTC)
Development of formulation in collaboration with Prof. Dr. Oliver Germershaus (FHNW)
Infrastructure
Bioreactors
Purification
Chromatography
Infrastructure (detailed)
Bioreactors for bacterial cultures: from 1 mL to 100 L
Bioreactors for mammalian cell cultures: from 1 mL to 10 L
High-throughput shaken cultivation systems (bacterial and mammalian)
Membranes and hollow fibers for cell and protein separation
Ultracentrifuge and pilot scale centrifugation
Clarification from small scale to pilot scale
Purification equipment: chromatography columns from 1 mL to 1000 mL (Äkta Avant, Äkta Pilot, ChromaCon Cube, Biorad)
Tangential flow filtration (TFF) units, ultrafiltration and diafiltration (UF/DF) (Pall Centramate, Äkta Flux)
Inline/online sensors (Raman, IR, capacitive sensors)
Biotechnet platforms
Training for Pharma / Biotech
Biomanufacturing
Group leader
Thomas Villiger
Academic institution
FHNW - University of Applied Sciences and Arts Northwestern Switzerland
Location
Hofackerstrasse 30, 4132 Muttenz, Switzerland
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Events
Continuous Chromatography for mAbs/Oligonucleotides and Peptides
Digital Methods in Life Sciences: Advancing Digitalisation in Biomanufacturing for the Pharmaceutical Industry
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