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    Organic and Medicinal Chemistry Verified listing Verified listing

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    We can help you

    With our medicinal chemistry expertise, structure-based design and organic synthesis, we can work with you to develop new treatment options for patients.

    Our research activities are focused on the organic synthesis and analyses of functional molecules at the interface between chemistry and biology with an emphasis on the development of clinical drug candidates for therapeutically relevant indications.

    Competencies
    • Drug Development
    • Biologics
    Competencies (detailed)
    • Medicinal chemistry
    • structural analysis of the target protein (X-ray analysis of co-crystal structures)
    • NMR binding studies (ligand/protein)
    • fragment-based design of novel ligands
    • effective application of industry standard docking software
    • multi-step organic synthesis of ligands
    • establishment of structure activity relationships (SAR)
    • development of data bank based IT solutions for the information management of chemical and biological data (SAR, inventory, etc.)
    • Organic Synthesis + Synthetic Methodology
    • Organic Analysis + Structure Elucidation
    • Cheminformatics
    Infrastructure
    • Chromatography
    • Mass Spectrometry
    Infrastructure (detailed)
    • Thermo MSQ Plus UHPLC‐single quadrupole system
    • Liberty Blue Automated Microwave Peptide Synthesizer
    • Bruker AVANCE III HD 500MHz OneBay NMR Spectrometer
    • Waters Xevo-Acquity UPLC-triple quadrupole system
    • Gilson PLC 2020 Purification system
    • LC-MS Agilent Ion Trap XCT
    • Knauer preparative HPLC System: flow rate up to 500 ml/min
    • Ehrfeld and Little Things Factory semi-automatic microreactor synthesis equipment
    • Radleys parallel synthesis equipment
    • ISCO chromatography system
    • GeneVac EZ-2 evaporation system
    • lab reactor LabMax: automatic synthesis (-40 °C to 140 °C)
    • ChemSpeed PSW 1100: automatic peptide synthesis equipment
    • Biotage, MLS System: microwave assisted synthesis equipment
    • Büchi autoclave systems: up to 50 bar and maximum 1 litre
    • industry sized evaporation system Büchi R-220
    • Perkin-Elmer 341 polarimeter, FTIR, GC
    Group leader
    Rainer Riedl
    Academic institution
    ZHAW ICBT - Zurich University of Applied Sciences - Institute for Chemistry and Biotechnology
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