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    Cell Physiology and Cell Engineering

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    Developing in vitro assays as close as possible to human physiology with a quantitative read-out.

    • Using our own iPSCs, modify them genetically if required and differentiate them to the desired cell type.
    • Using primary cells, modify them genetically if required to build the desired in vitro model.
    • Developing reporter systems that are integrated into the genome, which provides a quantitative read-out.

    Examples include:

    • 3D epidermis model using primary keratinocytes with a reporter system for oxidative stress
    • in vitro model of the blood brain barrier using brain microvascular endothelial cells derived from iPSCs.

     

    Generating antibodies against complex membrane proteins such as GPCRs and ion channels.

    • Using our rabbit cell lines to express the human protein of interest and our immunization protocol of rabbits with these cells, generating a strong immune response against the human protein in its native conformation.

    Examples include:

    • Antibodies against GPR137
    Gallery
    Competencies
    • Cell and Tissue Engineering
    • Drug Development
    • Stem Cells
    • In Vitro Assays
    Competencies (detailed)
    • in vitro test systems
    • Antibodies
    • Cell cultures with primary cells and cell lines
    • Cosmetics
    • Lab grown meat
    • Cell therapeutics based on hMSCs and iPSCs
    • Cell cultivation techniques
    • Mammalian cell culture (CHO-S, CHO-K1, HEK293F, HEK293T, etc)
    Infrastructure
    • Cell Culture
    • Biosafety Level 2
    • Flow Cytometry
    • Microscopy
    Infrastructure (detailed)
    • Confocal immunofluorescence microscopes
    • Fluorescence microscopy
    • Ultracentrifugation 100'000g-250'000g
    • FACS BD AriaIII
    • scanning electron microscope with environmelntal module (biological samples)
    Biotechnet platforms
    TEDD - Tissue Engineering for Drug Development and Substance Testing
    Successful projects
    Biotechnet Projects 2013-2015 - Funded by the CTI
    Biotechnet Projects 2016-2017: National Thematic Network Biotechnology
    Group leader
    Jack Rohrer
    Academic institution
    ZHAW - Zurich University of Applied Sciences
    Location

    Einsiedlerstrasse 31, Wädenswil, Switzerland

    Get Directions
    Events
    TEDD University Visit: Zurich University of Applied Sciences TEDD Competence Centre
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