Cell Physiology and Cell Engineering

Developing in vitro assays as close as possible to human physiology with a quantitative read-out.

• Using our own iPSCs, modify them genetically if required and differentiate them to the desired cell type.
• Using primary cells, modify them genetically if required to build the desired in vitro model.
• Developing reporter systems that are integrated into the genome, which provides a quantitative read-out.

Examples include:

• 3D epidermis model using primary keratinocytes with a reporter system for oxidative stress
• in vitro model of the blood brain barrier using brain microvascular endothelial cells derived from iPSCs.

Generating antibodies against complex membrane proteins such as GPCRs and ion channels.

• Using our rabbit cell lines to express the human protein of interest and our immunization protocol of rabbits with these cells, generating a strong immune response against the human protein in its native conformation.

Examples include:

• Antibodies against GPR137