Developing in vitro assays as close as possible to human physiology with a quantitative read-out.
Using our own iPSCs, modify them genetically if required and differentiate them to the desired cell type.
Using primary cells, modify them genetically if required to build the desired in vitro model.
Developing reporter systems that are integrated into the genome, which provides a quantitative read-out.
3D epidermis model using primary keratinocytes with a reporter system for oxidative stress
in vitro model of the blood brain barrier using brain microvascular endothelial cells derived from iPSCs.
Generating antibodies against complex membrane proteins such as GPCRs and ion channels.
Using our rabbit cell lines to express the human protein of interest and our immunization protocol of rabbits with these cells, generating a strong immune response against the human protein in its native conformation.