Biopharmaceutical Production Processes

Stem Cells and Cell Therapy Manufacturing

• Scalable production of iPSCs and hMSCs
• Microcarrier and aggregate-based (spheroid) expansion strategies
• Downstream processing for cell therapies (washing, concentration, formulation)

Advanced Bioprocess Intensification

• Perfusion-based continuous manufacturing
• High-density cell culture processes and cell banking

Cell Line Engineering

• Clone selection and stability
• Understanding productivity variability at the single-cell level
• Effect on process design and development

Modeling and Digital Twins in bioprocessing

• Mechanistic modeling of cell metabolism and growth
• Hybrid models combining machine learning and mechanistic approaches
• Real-time process control using soft sensor or digital twins

PAT and Automation

• Integration of real-time monitoring and control strategies
• Automation and robotics in upstream processing