The aim of this seminar is to provide an introduction to continuous chromatography with hands-on practice with capture and polishing processes for biomolecules. These processes lead to improvements in productivity and manufacturing costs and may be even enabling in difficult purification challenges, such as antibody-drug conjugates or biosimilars. Attendees will acquire the basic tools to design, run and evaluate multicolumn processes and to quantify these improvements, serving as basis for an economic evaluation. As the least complex of all multi-column processes, the workshop is focused on twin column chromatography.
Introduction to continuous chromatography for biomolecules
Theory of multi-column chromatography
Design of multi-column chromatography processes
Hands-on training on twin column equipment capture and polishing applications
Process performance evaluation and scale-up
This workshop does not cover 4-zone SMB, chiral and small molecule separations.