1. History and mission
Bioinformatics platform of the Competence Center Personalized Medicine UZH/ETH
DNA Sequencing has changed biomedical research. Now focus is on Medicine: Routine genetic analysis shall make patient-tailored therapies standard. The Competence Center Personalized Medicine UZH/ETH (CC-PM) coordinates and actively supports interdisciplinary research of the University of Zurich, ETH Zurich and the University Hospitals in Zurich in the field of genome-based healthcare. Cooperation between basic and clinical research will be intensified through the Competence Center. Based on the genetic disposition of a person, methods for genome-guided prevention, diagnosis and therapy will be developed and implemented. The Center will build and provide the framework for generating and integrating multidimensional genomic and (epi)genetic datasets. As such, it will operate at the interface of life science, medicine and technology.
The CC-PM’s 36 professional members and their research groups bring expertise from many different departments of ETH and different medical faculties of the University Zurich and the University Hospitals of Zurich. The focus of CC-PM is research in genome-based personalized medicine. Associated with CC-PM are technology platforms to support these research activities. They offer specific services for the members. Initially, two technology platforms have been established, namely Biobanking led by UZH/USZ and NEXUS, led by ETH, which comprises high-throughput cell-based sreening and data management and analysis.
One of the two CC-PM platforms, the ETH platform “NEXUS Personalized Health Technologies”, was founded in January 2015 and is dedicated to enable and accelerate the continuum of research spanning discovery through translation to innovation in personalized medicine. NEXUS has two operative units: Theragnostics Discovery (TD), located at the ETH Hönggerberg campus, and Personalized Medicine Information and Communication Technology (PM-ICT), located at the ETH Zentrum campus, close to the University Hospital Zurich. These units offer advanced genomic data management, analytical tools and services, robotic systems for high-throughput screening and genome-scale as well as chemical biology tools to define and interfere with disease-causing cell circuits.
The TD Unit is built around three interconnected pillars: integrated robotic and imaging systems (HiRes robotics, Acumen Cellista, Tecan M1000 microplate reader, Roche PCR cycler); genome-scale screening and interfering tools (chemical libraries, lentiviral shRNA libraries, ORFeome collection, CRISPR/Cas sublibraries in development) and advanced cell systems (3D microtissues).
2. Platform members
The platform is lead by Dr. Silke Schneider, representing the CC-PM, which has currently 36 associated members from University Zurich, ETH and University Hospital Zurich working in research projects toghether with their outside-acadamia partners and industry.
UZH, USZ, ETH, HUG, UniL EPFL
2.3 How to become partner/member
CC-PM is open to scientists, physicians and clinicians of UZH, ETH and the University Hospitals in Zurich. In their role as members they engage in long-term research projects with different partners from outside academia and industry in the field of genome-based biomedical research with a strong emphasis on Personalized Medicine.
The technology platform usage fee is CHF 1000.- per member and year. Please contact. Dr. Silke Schneider for details.
3. Events and News
3.2 Upcoming events
Latsis Symposium ETH Zurich 2016: Personalized Medicine -Challenges and Opportunities
ETH Zurich, June 27–29, 2016
3.3 Past events
CC-PM/MTB Retreat Ittingen 2014, 2015
(no platform projects yet)
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